SyreniRing

SyreniRing is a flexible, hormone-releasing vaginal ring used primarily for contraception. It provides a convenient and effective method to prevent pregnancy. Here’s how it works and what it’s used for:

What is SyreniRing?

SyreniRing is a small, flexible ring made of plastic that is inserted into the vagina. It contains a combination of two hormones: etonogestrel (a progestin) and ethinyl estradiol (an estrogen). The ring is designed to be worn inside the vagina, where it continuously releases these hormones over a period of 3 weeks.

What is it used for?

Contraception: SyreniRing is primarily used to prevent pregnancy. It works by:

• Preventing Ovulation: The hormones inhibit the release of eggs from the ovaries
• Thickening Cervical Mucus: This makes it more difficult for sperm to travel through the cervix.
• Thinning the Uterine Lining: This reduces the likelihood of a fertilized egg implanting in the uterus.
• Menstrual Cycle Regulation: It can help regulate menstrual cycles and reduce the severity of menstrual symptoms.

SyreniRing offers a discreet and effective form of birth control, providing protection without the need for daily pills or frequent doctor visits.

Alternatives to SyreniRing

Alternatives to NuvaRing include various hormonal and non-hormonal contraceptive options:

1. Birth Control Pills: Daily oral contraceptives containing either a combination of estrogen and progestin or progestin only.
2. IUDs (Intrauterine Devices): T-shaped devices inserted into the uterus, available in hormonal and non-hormonal (copper) forms.
3. Contraceptive Patch: A skin patch that releases hormones absorbed through the skin.
4. Implant: A small rod inserted under the skin that releases progestin.
5. Contraceptive Injection: An injection of progestin given every three months.

For more options, consulting with a healthcare provider is recommended.

Sources

• SyreniRing, Patient Information Leaflet:
  
• https://www.crescentpharma.com...
• https://sh24.org.uk/contracept...

How to use SyreniRing

To use SyreniRing, follow these steps:

1. Insertion: Wash your hands, squeeze the ring, and insert it into the vagina. The exact position isn't crucial as long as it's comfortable.
2. Wearing Time: Keep the ring in place for three weeks.
3. Removal: After three weeks, remove the ring for a one-week break, during which you'll have your period.
4. New Cycle: Insert a new ring after the one-week break.

For detailed instructions on inserting SyreniRing into your vagina please read the patient leaflet:

Starting SyreniRing

If you have no used hormonal contraception in the past month

SyreniRing has to be inserted on the first day of the woman's natural cycle (i.e. the first day of her menstrual bleeding). Starting on days 2-5 is allowed, but during the first cycle a barrier method is recommended in addition for the first 7 days of SyreniRinguse.

If you are switching from a combined contraceptive pill

The woman should insert SyreniRing at the latest on the day following the usual tablet-free, patch-free or placebo tablet interval of her previous combined hormonal contraceptive.

If the woman has been using her previous method consistently and correctly and if it is reasonably certain that she is not pregnant she may also switch from her previous combined hormonal contraceptive on any day of the cycle.

If you are changing from a progesterone-only pill, injection, implant or IUD

The woman may switch on any day from the minipill (from an implant, or the IUS on the day of its removal, from an injectable when the next injection would be due)

You will need to use a barrier method of protection such as a condom for the first 7 days to avoid getting pregnant.

SyreniRing and missed ring insertion

What to do in case of a lengthened ring-free interval

The woman should insert a new ring as soon as she remembers. A barrier method such as a male condom should be used in addition for the next 7 days. If intercourse took place during the ring-free interval, the possibility of a pregnancy should be considered. The longer the ring-free interval, the higher the risk of a pregnancy.

What to do if the ring was temporarily outside the vagina

SyreniRing should be left in the vagina for a continuous period of 3 weeks. If the ring is accidentally expelled, it can be rinsed with cool to lukewarm (not hot) water and should be reinserted immediately.

If SyreniRing has been out of the vagina for less than 3 hours contraceptive efficacy is not reduced. The woman should reinsert the ring as soon as possible, but at the latest within 3 hours.

If SyreniRing has been out of the vagina, or is suspected to have been out of the vagina for more than 3 hours during the 1^st or 2^nd week of use, contraceptive efficacy may be reduced. The woman should reinsert the ring as soon as she remembers. A barrier method such as a male condom should be used until SyreniRing has been in the vagina continuously for 7 days. The longer the time SyreniRing has been out of the vagina and the closer this is to the ring-free interval, the higher the risk of a pregnancy.

If SyreniRing has been out of the vagina, or is suspected to have been out of the vagina for more than 3 hours during the 3^rd week of the three-week use period, contraceptive efficacy may be reduced. The woman should discard that ring, and one of the following two options should be chosen:

1. Insert a new ring immediately

Note: Inserting a new ring will start the next three-week use period. The woman may not experience a withdrawal bleed from her previous cycle. However breakthrough spotting or bleeding may occur.

2. Have a withdrawal bleeding and insert a new ring no later than 7 days (7x24 hours) from the time the previous ring was removed or expelled.

Note: This option should only be chosen if the ring was used continuously for the preceding 7 days.

If SyreniRing was out of the vagina for an unknown amount of time, the possibility of pregnancy should be considered. A pregnancy test should be performed prior to inserting a new ring.

What to do in case of lengthened ring-use

Although this is not the recommended regimen, as long as SyreniRing has been used for maximally 4 weeks, contraceptive efficacy is still adequate. The woman may maintain her one-week ring-free interval and subsequently insert a new ring. If SyreniRing has been left in place for more than 4 weeks, contraceptive efficacy may be reduced and pregnancy should be ruled out before inserting a new SyreniRing.

If the woman has not adhered to the recommended regimen and subsequently has no withdrawal bleed in the following ring-free interval, pregnancy should be ruled out before inserting a new SyreniRing.

SyreniRing ingredients

The active ingredients contained in SyreniRing are: ethinylestradiol, etonogestrel

NuvaRing is made of: Ethylene vinylacetate copolymer, 28% vinylacetate; ethylene vinylacetate copolymer, 9% vinylacetate and magnesium stearate.

SyreniRing side effects

The SyreniRing, a form of hormonal birth control, can have various side effects. The five most common ones include:

1. Vaginal Discharge or Irritation: Some users experience increased discharge or irritation in the vaginal area, which can be bothersome but is usually not severe.
2. Headaches: Hormonal changes from the NuvaRing can lead to headaches or migraines in some people.
3. Nausea: Like many hormonal contraceptives, NuvaRing can cause nausea, especially when first starting the ring or if it's not inserted properly.
4. Breast Tenderness: Hormonal fluctuations may cause your breasts to become sore or tender.
5. Mood Changes: Some users report mood swings or changes in their emotional state, which can be linked to hormonal changes.

Most of these side effects are usually mild and may diminish over time. If they are severe or persist, it's a good idea to talk to your healthcare provider.

SyreniRing warnings

SyreniRing carries several important warnings. It may increase the risk of serious cardiovascular events, especially in women over 35 who smoke. It is not recommended for women with a history of blood clots, certain cancers, liver disease, or uncontrolled high blood pressure. Additionally, SyreniRing should not be used during pregnancy or by women who have unexplained vaginal bleeding.

NuvaRing is unsuitable for you if you have:

• Ever had a blood clot in the leg or lungs
• A blood clotting disorder
• A history of heart attack or stroke
• Migraines with aura
• Impaired liver function
• A tumour in the liver
• Kidney failure
• Ever had cancer of the cervix, breast, vagina or uterus
• Unexplained vaginal bleeding
• An allergy to any of the ingredients of Yasmin

NuvaRing is unsuitable for you if you have suffered from any of the following problems while pregnant:

• Jaundice
• Pemphigoid gestationis (a rash involving blisters of the hands and feet)
• Pruritus

SyreniRing and cancer

NuvaRing, like other hormonal contraceptives, may slightly increase the risk of certain types of cancer, such as breast and cervical cancer. However, it also has protective effects against other cancers, including ovarian and endometrial cancers. The risk varies depending on individual factors such as family history, lifestyle, and duration of use.

For detailed information on the risks and benefits, consulting with a healthcare provider and reviewing official sources like the NuvaRing website is recommended.

SyreniRing and blood clots

NuvaRing has been associated with an increased risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). This risk is heightened in women with a history of clotting disorders, smoking, or prolonged immobilization. It's important to discuss individual risk factors with a healthcare provider before using NuvaRing. You are also at a heightened risk of developing a blood clot if you:

• Smoke
• Are obese
• Have a family history of blood clots
• Do not exercise regularly
• Have had a miscarriage in the past
• Have recently given birth

SyreniRing and other medicines

The following medicines may impact the effectiveness of NuvaRing:

• Epilepsy medicines (e.g. phenytoin, barbiturates, carbamazepine
• Tuberculosis medicines (e.g. rifampicin)
• HIV medicines
• Hepatitis C medicines (e.g. telaprevir, boceprevir)
• Antifungal medicines (e.g. ketoconazole)
• Arthritis medicines (e.g. etoricoxib)
• Bosentan
• St John’s Wort

SyreniRing may impact the effectiveness of the following medicines:

• Ciclosporin
• Theophylline
• Lamotrigine
• Tizanidine

Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.