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Malarone 250mg/100mg Tablets

Malarone 250mg/100mg Tablets

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Buy Malarone 250mg/100mg Tablets online

Malarone is one of the newest and best-known treatments to prevent malaria. It is taken daily before, during and after your trip to protect against malaria when travelling to at-risk areas. Malarone malaria prophylaxis tablets can be purchased online quickly and easily from The Independent Pharmacy Online Doctor, saving you money in the process. Don't waste time and money at expensive travel clinics, buy Malarone online today for peace of mind on your trip of a lifetime!

According to the latest statistics, malaria causes over one million deaths every year. It’s important to know the facts about prevention and treatment before you travel to a high-risk part of the world. Malaria is not a virus or a bacterial infection – rather it’s a parasite that multiplies in red blood cells.

Human malaria is caused by four different species of Plasmodium. These are:

  • P. falciparum
  • P. malariae
  • P. ovale
  • P. vivax

Malaria symptoms occur in stages, usually 48-hour cycles. The disease can be spread by animals and humans and is highly infectious. If a person suffering from malaria is not properly treated, they may have recurrences of the disease months later. With the right drugs, people with malaria can be cured and all the malaria parasites can be cleared.

Suitable for age: 18 years +
Consultation required?Yes

This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective.

Type of medicine
Anti-muscarinic
Works by
Killing the malaria parasite
Active ingredient
Atovaquone, Proguanil Hydrochloride
Effective within
N/A
Pack size
N/A
Strength
100mg of Proguanil Hydrochloride and 250mg of Atovaquone
Common side effects
Coughing, Diarrhoea, Dizziness, Headache, Loss of Appetite, Mouth Sores, Nausea, Stomach Pain, Vomiting, or Weakness
Manufacturer
GlaxoSmithKline
Generic
No
Use with alcohol
No known issues

Malarone Information

Malarone antimalarial prophylaxis

Malarone malaria tablets are available to buy from The Independent Pharmacy Online Doctor service following a free consultation, to help prevent malaria. To find out more about malaria and see all the available treatments, see our Malaria page.

What is Malarone?

Malarone is a branded antimalarial medication. Malarone pills contain two active ingredients: atovaquone and proguanil. They are used to prevent malaria spread by the bite of mosquitoes encountered in tropical countries whilst travelling.

Malarone tablets contain two active ingredients: proguanil hydrochloride and atovaquone. It is mainly used to prevent malaria. It is manufactured by GlaxoSmithKline and is classified as a prescription-only medicine (POM). Malarone is one of the newer treatments for malaria. It is taken once daily, 1-2 days before travel and continuing until 1 week after returning.

How does Malarone work?

Each Malarone tablet contains 100mg of proguanil hydrochloride and 250mg of atovaquone. Both of these ingredients are anti-parasitic drugs that are active against the malaria-causing plasmodium parasite. Once the plasmodium parasite enters the bloodstream, it starts to reproduce, causing malaria. Proguanil works by inhibiting the parasite’s ability to reproduce. It does this by blocking the action of an enzyme found inside the parasite. This enzyme, dihydrofolate reductase, is involved in its reproduction. By blocking dihydrofolate reductase, proguanil prevents the formation of any new genetic material forming within the parasite. This means it is unable to reproduce and multiply.

Atovaquone works in a similar way to proguanil. It inhibits the production of new genetic material from inside the malaria parasite, resulting in the parasite’s inability to reproduce. Both these ingredients work effectively together in a dual attack upon the malaria-causing parasite.

Malarone dosage instructions

  • As a prophylaxis, the recommended dosage is 1 tablet (250 mg/100 mg) daily, beginning 1-2 days before travel and continued 1 week after your return
  • As a malaria treatment - see your doctor as soon as possible if you have any symptoms of malaria
  • In the event of vomiting within 1 hour of taking Malarone, the dose should be repeated

Plasmodium falciparum

Malarone is highly effective against the strains of malaria caused by the plasmodium falciparum parasite. This parasite is responsible for producing the most serious form of malaria called malignant malaria. For areas where the plasmodium falciparum is prevalent, Malarone tablets will usually be the recommended choice of treatment. Malarone may also be ideal for other areas where there is a known resistance to other forms of antimalarial medicines, such as Chloroquine.

Atovaquone/Proguanil

Generic Malarone pills are also available in an unbranded form called Atovaquone/Proguanil. These antimalarial tablets are the same as Malarone, but are cheaper due to their unbranded nature.

Please read the patient information leaflet for side effects and additional information.

Pharmacist tip: Malarone should not be taken if you are pregnant or breastfeeding. It is generally very well tolerated, with only mild intestinal upsets and headaches reported. If side effects are experienced, then taking the tablets with or after a meal may help to relieve them.

Mosquito bite avoidance

It’s important to note that even if you’re taking an antimalarial like Malarone or generic Malarone, it’s still important to take steps to prevent mosquito bites. The use of insect repellents, nets and sleeping in a screened room are all highly recommended. It’s also a good idea to wear light-coloured clothing that covers as much of the body as possible.

Using an insecticide like a plug-in or spray is also an effective means of clearing and deterring those pesky insects. All of the above measures are particularly important after sunset. This is the time when mosquitoes are most active. As with so many things in life, prevention is better than cure. This is certainly true with regard to malaria!

There are currently no effective non-prescription alternatives for malaria treatment, however, you can take more steps in avoiding being bitten while away by:

  • Using mosquito repellent containing DEET.
  • Using a mosquito net treated with insecticide while you are sleeping.
  • Using a sunscreen designed to help prevent mosquito bites.

Use only recommended, evidence-based products. There is no evidence that bath oils, electronic buzzers, essential oils, garlic, homoeopathic remedies, odour-baited mosquito traps, tea tree oil, skin moisturisers, smoking, vitamin B tablets or yeast extract will have any effect in preventing mosquito bites.

Malaria zones

  • Africa and African countries, such as Kenya and Tanzania
  • South and Central America, including Peru, Mexico and the Dominican Republic
  • Some Asian countries, such as India, Cambodia, Thailand and Vietnam

If you look at a world map, it is usually the tropical areas in which malaria originates and spreads, since the conditions provide a good breeding ground for mosquitoes.

Malaria is caused by four different organisms all belonging to a family called plasmodium. The fiercest strain is Plasmodium falciparum, which can cause malignant malaria. Malarone is most effective against the falciparum strain and less effective against the others.

Malaria can lie dormant and resurface weeks, months or sometimes years after you return from your trip. Always see a doctor if you have flu-like symptoms up to a year after returning from a malaria zone.

Malarone vs. Doxycycline

  • Malarone is an antimalarial drug – Doxycycline is a tetracycline antibiotic
  • Doxycycline is cheaper than Malarone
  • Both kill the erythrocytic (blood) stages of the malaria parasite – Malarone also kills malaria parasites in the liver stage
  • Malarone should be taken for 7 days after leaving an infected area – Doxycycline must be taken for 4 weeks after
  • Both can lead to side effects of nausea, vomiting or abdominal pain – Doxycycline may also cause photosensitivity, which means your skin will burn much more easily in the sun

Malarone 250mg/100mg Tablets Patient Information Leaflet: https://www.medicines.org.uk/emc/product/947/pil

Malarone dosage

Malarone Summary

  • You should take one tablet every day at roughly the same time each day.
  • Malarone needs to be taken 1 – 2 days before entering an area where malaria is present and continued until 7 days after leaving the malaria area.
  • You should take Malarone with or after food or milk
  • Malarone remains effective with a moderate alcohol intake.

How and when do I take Malarone?

Malarone is a one-a-day dose that you need to start taking 1-2 days before you travel. It is continued every day during your stay and also for an additional week after you return to a Malaria-free area. For example if you were travelling for 2 weeks you would need 23 tablets. That’s 2 (before you travel) + 14 (during your stay) + 7 (upon your return) = 23 tablets.

It is important to complete the course as it can take 7 days to ensure any parasites that remain in your blood are effectively killed.

It is advised to take Malarone with food and drink where possible. This can increase the absorption of Malarone in the body, increasing its effectiveness and possibly reducing side-effects.

Malarone ingredients

Each Malarone tablet contains 100mg of Proguanil Hydrochloride and 250mg of Atovaquone as the active ingredients.

The other ingredients are:

Tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycolate (Type A), magnesium stearate.

Tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and polyethylene glycol 8000.

Malarone side effects

If you do experience side effects from Malarone they may include coughing, diarrhea, dizziness, headache, loss of appetite, mouth sores, nausea, stomach pain, vomiting, or weakness. Malarone has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines. Please read the Patient Information Leaflet enclosed with your medicine for a full list of side effects.

If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0333 2200 519. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.

Malarone warnings

Unfortunately, Malarone is not 100% effective at preventing malaria, however, it is still very effective if taken properly and combined with bite avoidance methods.

Remember it is also important to get the correct vaccinations for your trip before you travel. These should be administered around 6 weeks before you leave.

Remember, malaria can take up to a year to develop after you have been bitten. If you experience symptoms including headaches, night sweats and abdominal pain any time during your trip or up to one year afterwards you must see a doctor as soon as possible.

Things to be aware of before considering or taking Malarone.

Malarone isn’t suitable for everyone. Do not take or take if:

  • You are allergic to any of the ingredients
  • You have severe Kidney disease
  • You are pregnant or breastfeeding

Malarone can also interact with other medicines, it may not be suitable if taking any of the following:

  • Metoclopramide (anti-emetic)
  • Tetracycline, Rifampicin & Rifabutin (antibiotics)
  • Efavirenz (protease inhibitor)
  • Warfarin (anticoagulant)
  • Etoposide (cancer treatment)

Should you be taking any of the above medications it will be necessary to seek medical advice before deciding upon the most suitable treatment. Please read the Patient Information Leaflet enclosed with your medicines for further information.

Malarone 250mg/100mg Tablets FAQs

Related Treatments

We stock 5 other treatments for Malaria Tablets

Visit our Malarone 250mg/100mg Tablets page for treatments, advice and FAQs.

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Daniel Hurley

Reviewed by

Daniel Hurley
Daniel Hurley
MPharm IP
2078790
Pharmacist Independent Prescriber

Dan is an experienced pharmacist having spent time working in both primary and secondary care. He currently supports our clinical team by providing robust clinical governance review of our internal processes and information.