Evorel Sequi Patches

How to use Evorel Sequi

Evorel Sequi contains four Evorel 50 patches and 4 Evorel Conti patches. Evorel 50 should be applied twice a week for the first 2 weeks of each 4 week period, followed by twice-weekly changes of Evorel Conti. As soon as you remove your fourth Evorel 50 patch, replace it with the first Evorel Conti patch. Do not leave a break between packs.

• Change your patch on the same two days every week. This will mean that one patch is on for three days and the next patch for four days.
• Apply the patch to an area of skin that is dry and clean. Press down firmly to ensure that the patch is in place.
• Do not place the new patch on the exact same section of skin.
• Evorel should not be used on or around the breasts, broken skin or under elasticated parts of clothing.

For full details on how to use Evorel Sequi patches please read the Patient Information Leaflet contained within the product packaging.

Evorel Sequi ingredients

The active ingredients contained in Evorel Sequi are:

Evorel 50 Patches: Estradiol hemihydrate 3.2mg

Evorel Conti Patches: Estradiol hemihydrate 3.2mg, norethisterone acetate 11.2mg.

Evorel Sequi also contains the following inactive ingredients: Duro-Tak 387-2287, guar gum, Hostaphan MN19

Evorel Sequi side effects

Not everyone will experience side effects when they take Evorel Sequi, however, if you do they may include:

• Itchy or inflamed skin where the patch is applied
• Mood swings
• Anxiety
• Difficulty sleeping
• Nausea
• Headache
• Stomach pain
• Diarrhoea
• Muscle pain
• Breast pain
• Joint pain
• Weight gain
• Breakthrough bleeding
• Painful periods
• Fluid retention

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

Read our additional guide for more information about Evorel Sequi side effects.

Evorel Sequi warnings

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

The use of HRT – whether you choose tablets or patches – carries risks that should be considered when deciding whether to start using it. In your online consultation, you will be asked about your personal and family medical history. After starting treatment, you should see your doctor for regular check-ups and breast screening.

Evorel Sequi is unsuitable for you if you:

• Have ever had breast cancer
• May have cancer which is sensitive to oestrogen (including uterine cancer)
• Have untreated endometrial hyperplasia (an excessively thick womb lining)
• Suffer from a blood clotting disorder, or have ever had a blood clot
• Have recently had a heart attack or stroke
• Have a history of liver disease
• Suffer from porphyria (a rare hereditary blood disease)
• Are allergic to any of the ingredients in the patch

Inform your GP if you plan on using Evorel Sequi and have ever had any of the following health complications:

• Fibroids
• Unexplained vaginal bleeding
• Impaired liver function
• Uterine problems including endometriosis or endometrial hyperplasia
• Circulation problems (e.g. angina, heart attack)
• High risk of blood clots
• Diabetes
• Migraine
• Gallstones
• Systemic lupus erythematosus
• Asthma
• Epilepsy
• Fluid retention
• High blood pressure
• High fat levels in the blood
• Otosclerosis (a hereditary ear disorder)
• Thyroid problems
• A family history of breast cancer or another oestrogen-sensitive cancer
• A history of severe allergic reactions

Evorel Sequi and other medicines

Tell your GP or pharmacist if you have taken or plan to take any of the following medicines:

• Epilepsy medicines (e.g. lamotrigine, carbamazepine)
• Tuberculosis medicines (e.g. rifampicin)
• HIV medicines (e.g. nevirapine, ritonavir, nelfinavir)
• Bosentan (to reduce blood pressure in the lungs)
• St Johns Wort

Evorel Sequi and cancer

HRT may increase your risk of breast cancer and endometrial cancer. The extent of this risk will vary depending on the length of your HRT treatment and whether you are taking combined or oestrogen-only HRT. Check your breasts regularly for changes to the skin or nipple, or for any noticeable lump. For women who use HRT for more than 5 years, there may also be a slight increase in the risk of ovarian cancer.

Evorel Sequi and blood clots

Taking any form of HRT, including Evorel Sequi, can triple your chances of experiencing blood clots and make you 1.5 times more likely to experience a stroke. If you think you are developing symptoms of a blood clot at any time call NHS 111 or are having a stroke call 999.

Evorel Sequi, pregnancy and breastfeeding

Indivina should only be taken by postmenopausal women and is not a contraceptive. If you have had a natural period in the last year or you are under 50 years old you should discuss contraception options with your doctor before taking Indivina.

If you become pregnant while taking Indivina stop taking it straight away and contact your doctor. You should also not take Indivina while breastfeeding.

Please read all packaging and the Patient Information Leaflet contained within the product packaging before taking any new medicine and inform your doctor of medicines you are taking or intend to take.