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An infection is the result of a harmful organism (also known as a pathogen) entering your system and beginning to cause damage through spreading. The nature of the organism will vary depending on the situation, and each type of pathogen will have different effects. A bacterial infection is distinct from a viral infection, for instance, and must be treated differently.
A skin infection is simply an infection produced by an organism growing within (or adjacent to) your skin layers. They can begin by entering the skin through cuts or damage, but they can get into your tissue elsewhere and spread. Most skin infections will only significantly affect the skin itself, making them more uncomfortable than dangerous.
The ultimate cause of a skin infection is the introduction of the pathogen, but it’s also caused — or facilitated — by a vulnerability allowing that pathogen to enter the skin. Healthy skin is extremely effective at keeping infections at bay. If you suffer a skin abrasion or develop a condition that weakens your skin, it will leave you more susceptible to skin infections.